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Pharmacokinetics and Pharmacodynamics for Chemists Webcast Course |
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| Course Code: PKWEB |
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| This course presents the fundamentals of Pharmacokinetics and Pharmacodynamics as they apply to the chemical structure of drugs. There will be specific discussion of the role of medicinal chemistry in the drug discovery process; how chemical structure affects the absorption, distribution, metabolism and excretion (ADME properties) of drugs; and drug affinity and efficacy (Pharmacodynamics). In addition, students will learn the essentials of interpreting pharmacokinetic data from animal studies for prediction of first dose in humans and therapeutic use of drugs. By the end of this course, students should be able to understand the role of the medicinal chemist in the process of drug discovery and development. This course is centered on gaining an understanding of in vitro PK assay data (Caco-2, MDCK, PAMPA, microsomes, hepatocytes etc) to predict in vivo PK and optimize drug ADME properties. In vivo data interpretation (scaling from animal to humans, allometric plots) will be discussed with specific examples of the role of pharmacokinetics in drug development. |
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February 18 - March 25, 2010 |
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This course will meet for six online session from 11:00 am to 12:15 pm ET on the following dates:
February 18
February 25
March 4
March 11
March 18
March 25
Attendance at scheduled class times is NOT required. Registered participants can attend the course by viewing session recordings. |
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Event Location: |
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Online |
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System Requirements
You need a high-speed connection to the Internet and an up-to-date
version of your web browser. The audio portion of the live session
will be provided via VOIP and US toll-free conference call. VOIP is
dependent on the quality and speed of your internet connection so
a high-speed connection is strongly recommended. Those choosing to
use VOIP should also have a headset or microphone in order to
interact with the instructor. If not, we recommend you choose
the telephone option, or contact us
to purchase a headset for $5. |
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Early Registration: |
$945 (ends Feb. 4) |
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Standard Registration: |
$1095 |
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Each person attending must register individually for this course
The course fee includes a electronic access to the course materials.
Five for Four!
Register five people for one course, one person for five courses,
or any combination in between and your fifth registration is free.
Note: This discount is only available if you register by fax or mail
and mention this discount. May not be combined with any other offer. |
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- Hands-on exercises in PK to gain proficiency in PK analyses
- Principles of first-order (linear) kinetics and comparison with non-linear processes.
- Linkage of physicochemical properties of molecules and ADME properties
- Use of in vitro data (absorption Caco-2, PAMPA / metabolism microsomes, S9, hepatocytes) to predict PK in humans
- Discussion of in silico solutions to ADME problems
- Meaning and application of compartmental (vs. non-compartmental) models and their analysis.
- How ADME characteristics affect dosing and how drugs are used (i.e. once a day oral)
- Definition, measurement and inter-relationships among apparent volume of distribution, plasma protein binding, clearance and half-life.
- Critical issues in drug candidate selection.
- Factors affecting oral drug absorption and bioavailability.
- Relationships between PK and PD / system-independent measurement of drug activity
- pK-PD interface: drug requirements for activity in open (in vivo) systems
- Allometric scaling / interpretation of in vivo PK data
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| Terry Kenakin in is Principal Research Investigator Molecular Discovery in the Department of Assay Development at GlaxoSmithKline Research and Development and teaches Pharmacokinetics and Pharmacodynamics: Principles and Applications in Pre-Clinical Drug Development and webcasts A Pharmacology Primer for Chemists and Pharmacokinetics and Pharmacodynamics for Chemists. |
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