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Chemical Toxicology: A Chemist’s Roadmap to Reduce Bioactivation Liabilities in Drug Candidates |
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| Course Code: TOXI |
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| Increase your overall knowledge of mechanisms of drug metabolism mediated toxicity. |
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Date - TBA |
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Check-in opens at 7:30 a.m. on the first day of the course.
Course runs from 8:30 a.m. to 5:00 p.m. each day. |
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Event Location: |
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TBA |
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Early Registration: |
$795 |
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Advanced Registration: |
$895 |
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Standard Registration: |
$995 |
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The course fee includes a course binder and a continental breakfast each day.
Five for Four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. Note: This discount is only available if you register by fax or mail and mention this discount. May not be combined with any other offer. |
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- Mechanisms of bioactivation
- Enzyme systems involved in bioactivation
- Methods for screening for reactive metabolite formation
- Case studies of structural optimization to reduce the risk of metabolism-mediated toxicity
- Mechanisms leading to metabolism-mediated genotoxicity
- Covalent binding & relevance to toxicity
- In vivo models to study reactive intermediate generation
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| Christine Fandozzi works for Merck. |
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| Griff Humphreys works for the Department of Biotransformation, Bristol-Myers Squibb. |
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| Fred Guengerich is the Harry Pearson Broquist Professor of Biochemistry, Vanderbilt University School of Medicine. |
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| Kaushik Mitra works for the Department of Drug Metabolism, Merck Research Laboratories. |
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